According to Wikipedia, "Mutt and Jeff is an American newspaper comic strip created by Bud Fisher in 1907. It is commonly believed to be the first daily comic strip."
I occasionally read the strip when it appeared in the local newspapers when I was a kid. It was OK, but not one of my favorites and I did not even know who was Mutt and who was Jeff. (Mutt was the tall guy, while Jeff was the short guy.)
Yesterday, Meg Winters sent an e-mail informing me that yesterday's online reprint of the strip featured Mutt en femme. See it for yourself here.